Isotopically Labeled Compounds
Apexbio Technology LLC MK-2206 dihydrochloride 1032350-13-2 100mg
MK-2206 dihydrochloride (CAS 1032350-13-2) is a selective inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 This compound acts by suppressing phosphorylation of Akt at critical residues Thr308 and Ser473 thus effectively inhibiting the downstream Akt signaling pathway By disrupting Akt-mediated signaling MK-2206 promotes apoptosis in cancer cells and enhances susceptibility to chemotherapy agents In research contexts MK-2206 has demonstrated enhanced tumor-cell sensitivity when combined with etoposide or rapamycin highlighting its utility in cancer biology studies and therapy evaluations
Medchemexpress LLC D18 | 2230218-36-5 | 98.8% | 364.5 g/mol | C21H28N6 | 5 MG
D18 is a small-molecule TLR7/8 dual agonist and ADC cytotoxin used in immunology and oncology research. It activates TLR7 and TLR8, increases PD-L1 expression via epigenetic regulation, and is used as a building block for antibody-drug conjugate synthesis; supplied for laboratory research use only.
- Dual TLR7/8 agonist activity.
- Enhances PD-L1 expression through epigenetic regulation.
- Acts as an ADC cytotoxin suitable for antibody-drug conjugate synthesis.
- High reported purity (~98.8%).
- Supplied in small milligram quantities; soluble in DMSO.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC 2-Methyl-N,N-bis(methyl-d3)-3-(10H-phenothiazin-10-yl)propan-1-amine | 1346603-88-0 | MFCD28900690 | 99.6% | 304.48 g/mol | C18H16D6N2S | 5 MG
Alimemazine-d6 is a deuterium-labeled analogue of alimemazine supplied as a research-grade analytical standard. It is intended for laboratory use as an internal standard or tracer in quantitative analyses and supports accurate measurement in spectrometric and chromatographic workflows.
- High isotopic labeling for improved quantitation in MS and NMR.
- Chemical purity approximately 99.6%.
- Suitable as internal standard for NMR, GC-MS, and LC-MS.
- Solid form, white to off-white appearance.
- Recommended storage: 4°C, protect from light; in solvent: -80°C for 6 months, -20°C for 1 month.
- Molecular weight 304.48 g/mol; formula C18H16D6N2S.
Medchemexpress LLC Agomelatine-d6 | 1079389-42-6 | MFCD21363446 | 98.6% | 249.34 g/mol | C15H11D6NO2 | 10 MG
Agomelatine-d6 is a deuterium-labeled analogue of agomelatine provided as a research-grade isotopically labeled reference standard. It is intended for use in analytical quantification, method development, and pharmacokinetic studies targeting melatonin MT1/MT2 receptor activity and 5-HT2C-related pathways. Not for human or clinical use.
- Isotopically labeled internal standard for LC-MS/MS assays.
- Supports accurate quantification of agomelatine in biological matrices.
- High purity suitable for analytical and pharmacological studies.
- Available in milligram quantities for method development and validation.
- Supplied for research use only; not for clinical administration.
Medchemexpress LLC Tert-butyl-DCL | 1025796-31-9 | MFCD28898592 | 99.8% | 487.63 g·mol⁻¹ | C24H45N3O7 | 1 ML
Tert-butyl-DCL is a small-molecule inhibitor of prostate-specific membrane antigen (PSMA) supplied as a ready-to-use solution (10 mM in DMSO, 1 mL) with high reported purity used for biochemical and bioimaging research.
- Ready-to-use 10 mM solution in DMSO.
- Pack size: 1 mL.
- High purity (99.8%).
- CAS number 1025796-31-9 for exact identification.
- Molecular weight 487.63 g·mol⁻¹; formula C24H45N3O7.
Cambridge Isotope Laboratories N-HEXANE (D14, 98%), 5 G, 21666-38-6
N-HEXANE (D14, 98%), 5 G, 21666-38-6
Cambridge Isotope Laboratories PYRIDINE-D5 (D, 99.5%) +0.05% V/V TMS, 10 G, 7291-22-7
PYRIDINE-D5 (D, 99.5%) +0.05% V/V TMS, 10 G, 7291-22-7
Cambridge Isotope Laboratories CYCLOHEXANE-D12 (D, 99.5%), 10 X 1 G, 1735-17-7
CYCLOHEXANE-D12 (D, 99.5%), 10 X 1 G, 1735-17-7
Cambridge Isotope Laboratories METHYLENE CHLORIDE-D2 (D, 99.8%), 100 G, 1665-00-5
METHYLENE CHLORIDE-D2 (D, 99.8%), 100 G, 1665-00-5
Cambridge Isotope Laboratories 1,1,1,3,3,3-HEXAFLUOROISOPROPANOL-D2 (D, 98%), 5 G, 38701-74-5
1,1,1,3,3,3-HEXAFLUOROISOPROPANOL-D2 (D, 98%), 5 G, 38701-74-5
Cambridge Isotope Laboratories PYRIDINE-D5 (D, 99.5%) +0.05% V/V TMS, 50 G, 7291-22-7
PYRIDINE-D5 (D, 99.5%) +0.05% V/V TMS, 50 G, 7291-22-7
Cambridge Isotope Laboratories 1,4-DIOXANE-D8 (P-DIOXANE) (D, 99%), 25 G, 17647-74-4
1,4-DIOXANE-D8 (P-DIOXANE) (D, 99%), 25 G, 17647-74-4
Medchemexpress LLC Nadolol-d9 (SQ-11725-d9) | 94513-92-5 | 97.0% | 318.46 | C17H18D9NO4 | 10 MG
Nadolol-d9 is the deuterium-labeled analog of nadolol, a non-selective, orally active β-adrenergic receptor blocker used for analytical and research applications as a tracer or internal standard.
- Deuterium-labeled internal standard for quantitative analysis by NMR, GC-MS, and LC-MS.
- Non-selective β-adrenergic receptor blocker analog suitable for tracer and pharmacokinetic studies.
- High purity (97.0%) for reliable analytical performance.
- Molecular formula C17H18D9NO4 and molecular weight 318.46 g/mol.
- Off-white to light yellow solid appearance.
- Storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (6 months) or -20°C (1 month).
- Available in small analytical quantities, including 10 mg packs.
Medchemexpress LLC Psychosine-d5 (galactosylsphingosine-d5) | 2260670-12-8 | 99.0% | 466.66 | 100 UG
Psychosine-d5 is deuterium labeled Psychosine. Psychosine is a substrate of the galactocerebrosidase (GALC) enzyme and is a potential biomarker for Krabbe disease. It is a highly cytotoxic lipid that can induce cell death in various cell types.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes like deuterium have the potential to affect the pharmacokinetic and metabolic profiles of drugs